Gelation Dynamics, Formation Mechanism, Functionalization, and 3D Bioprinting of Silk Fibroin Hydrogel Materials for Biomedical Applications

Abstract

Silk fibroin (SF), derived from silk cocoon fibers (Bombyx mori), is a natural protein polymer known for its biocompatibility, biodegradability, and sustainability. The protein can be processed into various material formats suitable for a range of applications. Among these, SF hydrogels are useful in the biomedical field, such as tissue engineering, due to the tailorable structures and properties achievable through tuning the gelation process. Therefore, the focus of this contribution is to comprehensively review and understand the formation, gelation mechanism, dynamic control, and functionalization of SF hydrogels. Unlike previous reviews, this work delves into understanding the strategies..